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EURASIP Journal on Bioinformatics and Systems Biology provides research results related to signal processing and bioinformatics theories and techniques relevant to a wide area of applications in the new disciplines of genomics, proteomics, and systems biology. The journal offers a common platform for scientists from several areas including signal processing, bioinformatics, statistics, biology and medicine, who are interested in the development of algorithmic, mathematical, statistical, modeling, simulation, data mining, and computational techniques, as demanded by various applications in genomics, proteomics, system biology, and more general in health and medicine.